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LGD 4033 was developed with the goal of preventing muscle loss in the elderly and in those who suffer from muscle dystrophyor muscular atrophy and with use of a therapeutic agent which effectively promotes muscle recovery, and is non-invasive.[4] The study was supported by a grant from the NIH under award number R01DP93821 to the MGH and by the National Institute on Aging to Dr. Wang.

The study participants included healthy older adults, aged 80 years or older who agreed to participate in the study. Participants were recruited as part of the New York Genome Initiative, a consortium of 21 institutions and research institutes including the MGH. The genotyping used included a large study center dataset on DNA from 1,063 individuals, and a subset (n = 60) from the Boston Marathon volunteers. The genotyping sample set was chosen because of its potential for obtaining accurate estimates of allele frequencies in large cohorts.

A total of 694 participants met eligibility criteria for the study, including 541 controls matched to participants by demographics, age and race. All participants were provided written informed consent and underwent a physical examination and physical examination, and a blood sample, in accordance with the study protocol and the Institutional Review Board for Human Research at Harvard Medical School, the National Institutes of Health (NIH) Guide for the Protection of Human Subjects at the National Institutes of Health, the National Institutes of Health Research and Development Office, and the US Department of Veterans Affairs. The study was conducted in accordance with the Declaration of Helsinki and institutional review boards for clinical research at Harvard, Boston and Maine Children’s hospitals, and the MGH.

This study found that the use of LGD 4033 resulted in significantly greater reductions in total body adipose cell mass than the placebo group in all the groups analyzed.

“These findings provide the most compelling evidence to date that long term use of a protein-free carbohydrate supplement called LGD 4033 will be associated with significant weight loss at 4 to 6 months in healthy older adults. This is possible because LGD 4033 is safe when used in conjunction with lifestyle factors known to have beneficial effects on metabolic risk factors,” said Prof. Wang.

The LGD 4033 study findings are published in JAMA Medicine.

The study was performed with the assistance of Dr. David Yurko, Dr. John Krasnow, and Dr. William DeCarolis.

Image Source: The image is credited to D’Arcy J. Buss.

The research was funded by the NIH (NIH).

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