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Glucocorticoids may also affect thyroid function. In high doses, glucocorticoids reduce the conversion of active thyroxine (t4) to the more active. Being lipids, steroid hormones enter the cell by simple diffusion across the plasma membrane. In marked contrast, steroid hormones (testosterone, estradiol, progesterone, glucocorticoids and mineralocorticoids; figure 7. 3), and thyroid hormones, are. Previous studies on hormone analysis in hair have focused mostly on steroid hormones, especially t, e and f (supplementary table 1), though it has been well. The mechanism of action of the thyroid hormones is similar; they interact with intracellular receptors. Both the steroid and thyroid hormone-receptor complexes. Steroid and thyroid hormone receptors are hormone-dependent regulators of gene transcription. These nuclear proteins are structurally related and have. Steroid and thyroid hormones act to coordinate complex events involved in development, differentiation, and physiological response to diverse stimuli. Both the steroid and thyroid hormone-receptor complexes exert their actions by binding to specific nucleotide sequences in the dna of
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