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Proteins that are involved in breaking down muscle are downregulated, meaning less of them are madeand used.
When the proteins are overexpressed, they are called muscle wasting, and they are responsible for wasting a range of muscles. However, a lack of muscle wasting appears to be a common feature of many disorders that involve the liver and kidneys.
How it works: the immune system recognises the molecules that cause muscle wasting
Focusing on how the immune response to myofibrillar protein is linked to an underlying brain disease or dysfunction may therefore help people to overcome their muscle wasting disease.
While the exact mechanisms that make muscle wasting more severe are unknown, the fact that the immune system recognises the molecules that cause muscle wasting may be the key.
For example, certain proteins that can cause muscle wasting may be found in certain foods. Research published last year indicated that certain foods were linked to the development of obesity and obesity-linked diseases like diabetes, cardiovascular disease and diabetes in children, which could prove vital to understanding why obesity causes so many illnesses.
A study published in January found that obese children had reduced muscle strength and endurance at the onset of the disease. Researchers from the University of Cambridge had previously demonstrated that obesity may lead to impaired immune-system function in children; therefore, they believe this may be an underlying reason why young people are more likely to develop muscle wasting.
How to prevent: exercise to reduce muscle wasting
The body may also alter how it responds to protein overload in order to improve muscle function to fight off muscle wasting.
In a study from the University of Arizona, researchers found that obese subjects had lower levels of ‘mTOR’ – a muscle ‘mammalian target of rapamycin’ that prevents muscle wasting.
Researchers from the University of Arizona suggested that this might be a consequence of the increased levels of ‘MARK2’ or ‘Muscle Adaptive Response 2’ protein found in obese people, particularly in the skeletal muscle.
Researchers from the University of Arizona also demonstrated that obese people may have reduced levels of protein-related mTOR.
The evidence suggests that reducing your food intake may also reduce muscle wasting.
Another study at the University of Arizona showed that obese men had lower levels of ‘mTOR’ and muscle protein synthesis (muscle repair) when compared to other groups. This may be because the body has a reduced capacity to produce mTOR and thus may be involved in the pathogenesis of obesity related disorders.
What will be needed for further research: identifying the cause of muscle
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